prognosis.org kenneth baillie

Kenneth Baillie BSc MBChB PhD MRCP FRCA

Kenneth Baillie is a academic critical care doctor. His main research interest is the host genomics of susceptibility to infectious diseases and responses to hypoxia.

Click here to visit the Baillie lab pages at the Roslin Institute.

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Recent Publications

1. Microglial brain region-dependent diversity and selective regional sensitivities to aging.

Grabert K, Michoel T, Karavolos MH, Clohisey S, Baillie JK, Stevens MP, Freeman TC, Summers KM, McColl BW.
Nat Neurosci. 2016 Mar;19(3):504-16. PMID: 26780511

2. The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis.

Patarcic I, Gelemanovic A, Kirin M, Kolcic I, Theodoratou E, Baillie KJ, de Jong MD, Rudan I, Campbell H, Polasek O.
Sci Rep. 2015 Nov 3;5:16119. PMID: 26524966

3. Gateways to the FANTOM5 promoter level mammalian expression atlas.

Lizio M, Harshbarger J, Shimoji H, Severin J, Kasukawa T, Sahin S, Abugessaisa I, Fukuda S, Hori F, Ishikawa-Kato S, Mungall CJ, Arner E, Baillie JK, Bertin N, Bono H, de Hoon M, ... ...Carninci P, Hayashizaki Y, Forrest AR, Kawaji H.
Genome Biol. 2015 Jan 5;16:22. PMID: 25723102

4. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.

Arner E, Daub CO, Vitting-Seerup K, Andersson R, Lilje B, Drablos F, Lennartsson A, Ronnerblad M, Hrydziuszko O, Vitezic M, Freeman TC, Alhendi AM, Arner P, Axton R, Baillie JK, Beckhouse A, ... ...Forrest AR, Sandelin A, Carninci P, Hayashizaki Y.
Science. 2015 Feb 27;347(6225):1010-4. PMID: 25678556

5. Antiviral combinations for severe influenza.

Dunning J, Baillie JK, Cao B, Hayden FG.
Lancet Infect Dis. 2014 Dec;14(12):1259-70. PMID: 25213733

6. The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis.

Mair-Jenkins J, Saavedra-Campos M, Baillie JK, Cleary P, Khaw FM, Lim WS, Makki S, Rooney KD, Nguyen-Van-Tam JS, Beck CR.
J Infect Dis. 2015 Jan 1;211(1):80-90. PMID: 25030060

7. Translational genomics. Targeting the host immune response to fight infection.

Baillie JK.
Science. 2014 May 23;344(6186):807-8. PMID: 24855243

8. Stratified infection medicine: a call to arms.

Russell CD, Griffiths SJ, Baillie JK, Haas J.
Lancet Infect Dis. 2014 Jun;14(6):451. PMID: 24849724

9. A Case of Aneurism of the Carotid Artery.

Cooper A.
Med Chir Trans. 1809;1:1-12.1. PMID: 20895104

10. A promoter-level mammalian expression atlas.

Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassmann T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, Bertin N, Jorgensen M, ... ...Sandelin A, Hume DA, Carninci P, Hayashizaki Y.
Nature. 2014 Mar 27;507(7493):462-70. PMID: 24670764

11. An atlas of active enhancers across human cell types and tissues.

Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, ... ...Forrest AR, Carninci P, Rehli M, Sandelin A.
Nature. 2014 Mar 27;507(7493):455-61. PMID: 24670763

12. Open source clinical science for emerging infections.

Dunning JW, Merson L, Rohde GG, Gao Z, Semple MG, Tran D, Gordon A, Olliaro PL, Khoo SH, Bruzzone R, Horby P, Cobb JP, Longuere KS, Kellam P, Nichol A, Brett S, ... ...Openshaw PJ, Farrar J, Carson G, Baillie JK.
Lancet Infect Dis. 2014 Jan;14(1):8-9. PMID: 24355025

13. Transcriptional profiling of the human fibrillin/LTBP gene family, key regulators of mesenchymal cell functions.

Davis MR, Andersson R, Severin J, de Hoon M, Bertin N, Baillie JK, Kawaji H, Sandelin A, Forrest AR, Summers KM.
Mol Genet Metab. 2014 May;112(1):73-83. PMID: 24703491

14. Heteroresistance at the single-cell level: adapting to antibiotic stress through a population-based strategy and growth-controlled interphenotypic coordination.

Wang X, Kang Y, Luo C, Zhao T, Liu L, Jiang X, Fu R, An S, Chen J, Jiang N, Ren L, Wang Q, Baillie JK, Gao Z, Yu J.
MBio. 2014 Feb 11;5(1):e00942-13. PMID: 24520060

15. Network analysis reveals distinct clinical syndromes underlying acute mountain sickness.

Hall DP, MacCormick IJ, Phythian-Adams AT, Rzechorzek NM, Hope-Jones D, Cosens S, Jackson S, Bates MG, Collier DJ, Hume DA, Freeman T, Thompson AA, Baillie JK.
PLoS One. 2014 Jan 22;9(1):e81229. PMID: 24465370

16. Deciding authorship order.

Brennan PM, Jubb A, Baillie JK, Partridge RW.
BMJ. 2013 Dec 16;347:f7182. PMID: 24342630

17. State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans.

Who Mers-Cov Research Group .
PLoS Curr. 2013 Nov 12;5. pii: ecurrents.outbreaks.0bf719e352e7478f8ad85fa30127ddb8. PMID: 24270606

18. An updated systematic review of the role of host genetics in susceptibility to influenza.

Horby P, Nguyen NY, Dunstan SJ, Baillie JK.
Influenza Other Respir Viruses. 2013 Sep;7 Suppl 2:37-41. PMID: 24034482

19. An expression atlas of human primary cells: inference of gene function from coexpression networks.

Mabbott NA, Baillie JK, Brown H, Freeman TC, Hume DA.
BMC Genomics. 2013 Sep 20;14:632. PMID: 24053356

20. Modelling mutational and selection pressures on dinucleotides in eukaryotic phyla--selection against CpG and UpA in cytoplasmically expressed RNA and in RNA viruses.

Simmonds P, Xia W, Baillie JK, McKinnon K.
BMC Genomics. 2013 Sep 10;14:610. PMID: 24020411

21. Influenza--time to target the host?

Baillie JK, Digard P.
N Engl J Med. 2013 Jul 11;369(2):191-3. PMID: 23841736

22. Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma.

Shukla R, Upton KR, Munoz-Lopez M, Gerhardt DJ, Fisher ME, Nguyen T, Brennan PM, Baillie JK, Collino A, Ghisletti S, Sinha S, Iannelli F, Radaelli E, Dos Santos A, Rapoud D, Guettier C, ... ...Ciccarelli FD, Garcia-Perez JL, Faivre J, Faulkner GJ.
Cell. 2013 Mar 28;153(1):101-11. PMID: 23540693

23. Wide variation and systematic bias in expert clinicians' perceptions of prognosis following brain injury.

Moore NA, Brennan PM, Baillie JK.
Br J Neurosurg. 2013 Jun;27(3):340-3. PMID: 23461749

24.

25. Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages.

Schroder K, Irvine KM, Taylor MS, Bokil NJ, Le Cao KA, Masterman KA, Labzin LI, Semple CA, Kapetanovic R, Fairbairn L, Akalin A, Faulkner GJ, Baillie JK, Gongora M, Daub CO, Kawaji H, ... ...Hayashizaki Y, Lenhard B, Hume DA, Sweet MJ.
Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):E944-53. PMID: 22451944

26.

27.

28. Somatic retrotransposition alters the genetic landscape of the human brain.

Baillie JK, Barnett MW, Upton KR, Gerhardt DJ, Richmond TA, De Sapio F, Brennan PM, Rizzu P, Smith S, Fell M, Talbot RT, Gustincich S, Freeman TC, Mattick JS, Hume DA, Heutink P, Carninci P, Jeddeloh JA, Faulkner GJ.
Nature. 2011 Oct 30;479(7374):534-7. PMID: 22037309

29. Complete genome sequence of methicillin-sensitive Staphylococcus aureus containing a heterogeneic staphylococcal cassette chromosome element.

Li D, Chu Y, Ren L, Li X, Yuan L, Kang Y, Zhang W, Yang Y, Wang X, Baillie JK, Yu J, Gao Z.
Sci China Life Sci. 2013 Mar;56(3):268-74. PMID: 23526394

30. Retinal vessel tortuosity in response to hypobaric hypoxia.

MacCormick IJ, Somner J, Morris DS, MacGillivray TJ, Bourne RR, Huang SS, MacCormick A, Aspinall PA, Baillie JK, Thompson AA, Dhillon B.
High Alt Med Biol. 2012 Dec;13(4):263-8. PMID: 23270443

31. Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations.

Kobayashi A, Donaldson DS, Kanaya T, Fukuda S, Baillie JK, Freeman TC, Ohno H, Williams IR, Mabbott NA.
DNA Res. 2012 Oct;19(5):407-22. PMID: 22991451

32. Is somatic retrotransposition a parasitic or symbiotic phenomenon?

Upton KR, Baillie JK, Faulkner GJ.
Mob Genet Elements. 2011 Nov 1;1(4):279-282. PMID: 22545239

33.

34. Sildenafil citrate for the prevention of high altitude hypoxic pulmonary hypertension: double blind, randomized, placebo-controlled trial.

Bates MG, Thompson AA, Baillie JK, Sutherland AI, Irving JB, Hirani N, Webb DJ.
High Alt Med Biol. 2011 Fall;12(3):207-14. PMID: 21962063

35.

36. High altitude pulmonary oedema.

Hall DP, Duncan K, Baillie JK.
J R Army Med Corps. 2011 Mar;157(1):68-72. PMID: 21465914

37. Incidence and predictors of acute mountain sickness among trekkers on Mount Kilimanjaro.

Jackson SJ, Varley J, Sellers C, Josephs K, Codrington L, Duke G, Njelekela MA, Drummond G, Sutherland AI, Thompson AA, Baillie JK.
High Alt Med Biol. 2010 Fall;11(3):217-22. PMID: 20919888

38. Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations.

Mabbott NA, Kenneth Baillie J, Hume DA, Freeman TC.
Immunobiology. 2010 Sep-Oct;215(9-10):724-36. PMID: 20580463

39. Medicine at high altitudes: danger and opportunity.

Baillie JK.
Journal of the Royal College of Physicians of Edinburgh 2009; 39:162-5.

40. Passage of pathogenic microorganisms through breathing system filters used in anaesthesia and intensive care.

Scott DH, Fraser S, Willson P, Drummond GB, Baillie JK.
Anaesthesia. 2010 Jul;65(7):670-3. PMID: 20374232

41.

42. Measurement errors caused by incompatibility of apparatus.

Paul A, Baillie JK, Drummond GB.
Eur J Anaesthesiol. 2009 Nov;26(11):977-80. PMID: 19707147

43.

44. Oral antioxidant supplementation does not prevent acute mountain sickness: double blind, randomized placebo-controlled trial.

Baillie JK, Thompson AA, Irving JB, Bates MG, Sutherland AI, Macnee W, Maxwell SR, Webb DJ.
QJM. 2009 May;102(5):341-8. PMID: 19273551

45. NT-proBNP does not rise on acute ascent to high altitude.

Toshner MR, Thompson AA, Irving JB, Baillie JK, Morton JJ, Peacock AJ.
High Alt Med Biol. 2008 Winter;9(4):307-10. PMID: 19115915

46.

47. Contamination of anaesthetic machines with pathogenic organisms.

Baillie JK, Sultan P, Graveling E, Forrest C, Lafong C.
Anaesthesia. 2007 Dec;62(12):1257-61. PMID: 17991263

48.

49. Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude.

Baillie JK, Bates MG, Thompson AA, Waring WS, Partridge RW, Schnopp MF, Simpson A, Gulliver-Sloan F, Maxwell SR, Webb DJ.
Chest. 2007 May;131(5):1473-8. PMID: 17494796

50.

51.

52.

53. Pericardial effusions in healthy lowlanders after acute ascent to high altitude.

Thompson AA, Baillie JK, Toshner M, Maxwell SR, Webb DJ, Irving JB.
Heart. 2006 Apr;92(4):539-40. PMID: 16537774

54. The mechanism of action of gabapentin in neuropathic pain.

Baillie JK, Power I.
Curr Opin Investig Drugs. 2006 Jan;7(1):33-9. PMID: 16425669

55. Drotrecogin alfa (activated) in severe sepsis.

Baillie JK, Murray G.
N Engl J Med. 2006 Jan 5;354(1):94-6. PMID: 16395834

56. The Chacaltaya High Altitude Laboratory.

Baillie JK, Thompson AAR, Bates MGD, Schnopp MS, Simpson A, Partridge R.
Journal of the Royal College of Physicians of Edinburgh 34: 130-133.

57. Morphine, gabapentin, or their combination for neuropathic pain.

Baillie JK, Power I.
N Engl J Med. 2005 Jun 23;352(25):2650-1. PMID: 15972877